Stabilizer distribution on surface of solid lipid microparticles and SLM stability: mesoscale simulation and experiments

ZHANG Lijuan; LONG Chunxia; QIAN Yu; LIU Lei

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Stabilizer distribution on surface of solid lipid microparticles and SLM stability: mesoscale simulation and experiments

更新时间：2025-12-10

- Stabilizer distribution on surface of solid lipid microparticles and SLM stability: mesoscale simulation and experiments
- CIESC Journal Issue 1, (2007)
- 作者机构：
  
  华南理工大学化工学院
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：05 January 2007，
  
  Published：05 January 2007
- 稿件说明：
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ZHANG Lijuan, LONG Chunxia, QIAN Yu, et al. Stabilizer distribution on surface of solid lipid microparticles and SLM stability: mesoscale simulation and experiments[J]. CIESC Journal, 2007, (1).
DOI：

ZHANG Lijuan, LONG Chunxia, QIAN Yu, et al. Stabilizer distribution on surface of solid lipid microparticles and SLM stability: mesoscale simulation and experiments[J]. CIESC Journal, 2007, (1). DOI：

摘要

用耗散粒子动力学（DPD）方法研究了稳定剂在负载布洛芬的固体脂质微颗粒（solid lipid microparticles

SLM）表面的分布状况。模拟结果表明：以卵磷脂为稳定剂，当布洛芬的摩尔分数为1%和2%时，卵磷脂较好地包覆在颗粒的表面；而当布洛芬的摩尔分数增大到3%和5%时，卵磷脂不能覆盖在布洛芬分子密集的部位。以poloxamer 407和PVA为稳定剂，随着布洛芬摩尔分数由1%增大到5%，稳定剂都能很好地包覆在颗粒的表面。实验现象较好地吻合了模拟结果。采用DPD模拟方法，可以加深了解多相复杂载药体系的微观结构并对实验现象进行分析，为SLM稳定剂的筛选提供理论指导。

Abstract

Dissipative particle dynamics (DPD) simulation was used to model the distribution of stabilizers (lecithin

poroxamer and PVA)on the surface of ibuprofen-loaded solid lipid microparticles (SLM).It was shown from DPD simulation results that lecithin totally enwrapped the surface of SLM when the molar fraction of ibuprofen was 1% and 2%.However

when the molar fraction of ibuprofen was increased to 3% and 5%

lecithin could not cover the place with a higher concentration of ibuprofen molecules.Poloxamer 407 and PVA totally enwrapped the surface of SLM when the molar fraction of ibuprofen was increased from 1% to 5%.The experimental results could be interpreted with the simulation results.DPD simulation provides an insight into the microstructure of a drug carrier and helps to analyze the experimental results

which is helpful in stabilizer selection for SLM.

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