Preparation and characterization of TOSPA complex

WU Fuzhong; LONG Zhongzhu; ZHANG Ping; CAI Shuihong; ZHAO Hongliang

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Preparation and characterization of TOSPA complex

更新时间：2025-12-10

- Preparation and characterization of TOSPA complex
- CIESC Journal Issue 10, Pages: 2731-2737(2010)
- 作者机构：
  
  1. 华东理工大学化工学院
  2. 上海东岳生物化工有限公司
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：05 October 2010，
  
  Published：05 October 2010
- 稿件说明：
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WU Fuzhong, LONG Zhongzhu, ZHANG Ping, et al. Preparation and characterization of TOSPA complex[J]. CIESC Journal, 2010, (10): 2731-2737.
DOI：

WU Fuzhong, LONG Zhongzhu, ZHANG Ping, et al. Preparation and characterization of TOSPA complex[J]. CIESC Journal, 2010, (10): 2731-2737. DOI：

摘要

1′

6′-三氯-2

3′

4′-五乙酰基蔗糖（TOSPA）是全基团法制备三氯蔗糖的关键中间体，采用苄基三乙基氯化胺（TEBA）为催化剂，氯化亚砜为氯化剂合成了TOSPA。研究结果表明：氯化亚砜用量、反应温度对收率有较大影响，当氯化亚砜过量50％，90℃下反应6 h，收率达到90％。实验中制备了TOSPA与甲苯的复合物，并经X射线单晶衍射、核磁、红外、元素分析进行了验证。利用TOSPA与甲苯复合物的物理特性，分离纯化得到了高纯度的TOSPA，具有工业化应用的前景。

Abstract

1′

6′-Trichloro-2

3′

4′-sucrose pentaacetate（TOSPA）

as the key intermediate of sucralose

was synthesized by chlorination which treated with thionyl chloride and catalyst TEBA.The yield was up to 90% by applying the optimized conditions ［SOCl2 150% (mol)

toluene

90℃

6 h］which was explored by the two important factors including amount of thionyl chloride and reaction temperature.The TOSPA complex was formed by mono-TOSPA and mono-toluene which was characterized by X-ray

H NMR

IR and EA.The TOSPA with high purity was obtained by separation utilizing the complex physical characteristic. The process is of potential for industrial application.

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