Sub-microweighing technique for measurement of partitioning of drugs between supercritical fluid and impregnated polymer

MA Shaoling; LU Zhaowen; BI Erli; WU Youting; ZHANG Zhibing; MENG Weimin

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Sub-microweighing technique for measurement of partitioning of drugs between supercritical fluid and impregnated polymer

更新时间：2025-12-10

- Sub-microweighing technique for measurement of partitioning of drugs between supercritical fluid and impregnated polymer
- CIESC Journal Issue 8, Pages: 2041-2045(2008)
- 作者机构：
  
  南京大学化学化工学院,江苏,南京,210093
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：05 August 2008，
  
  Published：05 August 2008
- 稿件说明：
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MA Shaoling, LU Zhaowen, BI Erli, et al. Sub-microweighing technique for measurement of partitioning of drugs between supercritical fluid and impregnated polymer[J]. CIESC Journal, 2008, (8): 2041-2045.
DOI：

MA Shaoling, LU Zhaowen, BI Erli, et al. Sub-microweighing technique for measurement of partitioning of drugs between supercritical fluid and impregnated polymer[J]. CIESC Journal, 2008, (8): 2041-2045. DOI：

摘要

Abstract

A high-pressure quartz crystal microbalance (QCM) apparatus was developed to investigate the absorption of carbon dioxide in two glassy polymer films—polystyrene (PS) and polyvinylpyrrolidone (PVP) at 40℃ and pressure up to 9.0 MPa.PVP was shown to have better CO2 absorption and chosen as the representative for supercritical impregnation of two model drugs—o-aminobenzoic acid and ibuprofen at 40℃ and pressure up to 8.0 MPa.It was found that the two impregnants were embedded into the polymer with a partition coefficient as high as 104 order of magnitude.Since the sub-microweighing technique established and utilized in this study was simple

convenient and accurate

it was believed that the technique could have wide and effective applications in supercritical impregnation processes.

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