Hydrolysis of cyclohexanone oxime promoted by β-cyclodextrin is helpful for protection and deprotection of groups in organic synthesis

thus leading to environment protection.β-Cyclodextrin was used as a catalyst for the hydrolysis of cyclohexanone oxime

since it could activate the substrate and promote its solubility.Various factors including catalyst

reaction temperature

amount of β-cyclodextrin

amount and variety of acid were investigated.β-Cyclodextrin could significantly promote the hydrolysis by interacting with acid

the yield of cyclohexanone was increased from 73% up to 92% by adding β-cyclodextrin at 60℃.Besides

the variety and amount of acids greatly influenced the reaction.Strong acids were much superior to weak acids for the present deprotection reaction.