Determination and correlation of natamycin solubilities in water and methanol

LUO Jianmei; JIN Zhihua; CEN Peilin; WANG Min

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Determination and correlation of natamycin solubilities in water and methanol

更新时间：2025-12-10

- Determination and correlation of natamycin solubilities in water and methanol
- CIESC Journal Issue 2, Pages: 281-286(2008)
- 作者机构：
  
  浙江大学宁波理工学院生物与制药工程系，浙江大学材料与化学工程学院化学工程与生物工程学系，天津科技大学生物工程学院，天津市工业微生物重点实验室
- 作者简介：
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- Online First：05 February 2008，
  
  Published：05 February 2008
- 稿件说明：
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LUO Jianmei, JIN Zhihua, CEN Peilin, et al. Determination and correlation of natamycin solubilities in water and methanol[J]. CIESC Journal, 2008, (2): 281-286.
DOI：

LUO Jianmei, JIN Zhihua, CEN Peilin, et al. Determination and correlation of natamycin solubilities in water and methanol[J]. CIESC Journal, 2008, (2): 281-286. DOI：

摘要

平衡法测定了纳他霉素在纯水(278.2～341.2 K)、甲醇(278.2～313.2 K)和不同水-甲醇比例混合溶剂（278.2～308.2 K）中的溶解度。采用人工神经网络对纳他霉素在纯水和甲醇中的溶解度数据进行关联，效果令人满意。纳他霉素在不同水-甲醇比例混合溶剂中的溶解度随温度的升高而增加，随水比例的增加而减少。采用非线性最小二乘法将实验数据关联为λh方程的形式，取得较好的效果，其中，λ、h可表达为水-甲醇比例的函数，用于内插计算，精度满足工程需要。实验得到的溶解度数据和关联结果对纳他霉素结晶工艺的研究具有较大的指导意义。

Abstract

The solubility data of natamycin in pure water (278.2—341.2 K)

methanol (278.2—313.2 K) and water-methanol mixture (278.2—308.2 K) were experimentally determined by the equilibrium method.The data in pure water and methanol were well correlated by artificial neural network.It was found that the solubilities of natamycin in the water-methanol mixture increased with the increase of temperature but decreased with the increase of water content.The solubility data were also well correlated in the form of λh equation by the nonlinear least square technique.The parameters λ and h were expressed by the function of water-methanol ratio.The results by interpolating calculation were satisfactory to some degree

which can be used in the industrial crystallization technology of natamycin.

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