Reaction kinetics of synthesis of thioether by visualization technique

HU Fangfeng; CHEN Jinfang; XU Junhui; CHEN Zhong

您当前的位置：

首页 >

文章列表页 >

Reaction kinetics of synthesis of thioether by visualization technique

更新时间：2025-12-10

- Reaction kinetics of synthesis of thioether by visualization technique
- CIESC Journal Issue 9, Pages: 2249-2254(2007)
- 作者机构：
  
  武汉工程大学化工与制药学院，湖北省新型反应器与绿色化学工艺重点实验室
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：05 September 2007，
  
  Published：05 September 2007
- 稿件说明：
移动端阅览
HU Fangfeng, CHEN Jinfang, XU Junhui, et al. Reaction kinetics of synthesis of thioether by visualization technique[J]. CIESC Journal, 2007, (9): 2249-2254.
DOI：

HU Fangfeng, CHEN Jinfang, XU Junhui, et al. Reaction kinetics of synthesis of thioether by visualization technique[J]. CIESC Journal, 2007, (9): 2249-2254. DOI：

摘要

采用光电显微技术和数字图像跟踪处理技术，实现了液-液界面亚微观环境的可视化。在微型反应器中研究了兰索拉唑中间体硫醚（2-[3-甲基-4-(2，2，2-三氟乙氧基)-2-吡啶基]-硫醚-1H-苯并咪唑）的界面合成反应。用数字图像灰度方法建立了浓度-灰度标准曲线，得到了硫醚界面合成反应动力学曲线和反应速率方程，计算出了咪唑钠和溴代吡啶由主体相到达界面相的总平均传质阻力。

Abstract

A novel technique combining photoelectronic microscopy and computer imaging tracing was used to investigate the synthesis of thioether(2-[3-methyl-4-(2

2-trifluoro-ethoxy)-pyridine-2-(methylsulfanyl)]-1H-benzoimidazole)

which is an intermediate for lansoprazole.Visualization in sub-microcosmic surroundings was realized to study interfacial phenomenon.The reaction kinetics study by a visualization technique was carried out in a mini-reactor

and the concentration-gray scale standard curves for thioether were obtained by analyzing the gray scales of digital images.Based on the concentration-gray scale standard curves

the reactant concentrations at different times were calculated

and the reaction kinetics curve and reaction rate equation were obtained.Also the total mass-transfer resistance from bulk phase to interface of sodium imidazole and bromopyridine was obtained.Liquid-liquid interface of synthesizing thioether was observed and its mass transfer mechanism was discussed.

关键词

Keywords

references

Views

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Bi-steady state reaction kinetics of nitrile hydratase in free resting cells

Reaction kinetics for oxygen oxidation desulfurization of catalytic cracking gasoline

Development and application of micro kinetic analyzer for fluidized bed gas-solid reactions

Reaction kinetics of phenylacetonitrile hydrolysis in NH3-enriched high temperature liquid water

Oxidation of catechol catalyzed by β-cyclodextrin-Cu(Ⅱ) complexes and its reaction kinetics

Related Author

SHEN Zhongyao

SUN Xudong

YU Huimin

SUN Yunpeng

SHEN Lian

WU Lijun

YUAN Haikuan

REN Jie

Related Institution

清华大学化学工程系生物化工研究所

浙江工业大学化工与材料学院

北京恒久科学仪器厂

湘潭大学化工学院

中国科学院过程工程研究所多相复杂系统国家重点实验室

⁰