Estimation and control of yield of cephalosporin C separated from fermentation broths by ceramic membrane

WANG Longyao; XING Weihong; YANG Gang; XU Nanping

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Estimation and control of yield of cephalosporin C separated from fermentation broths by ceramic membrane

更新时间：2025-12-10

- Estimation and control of yield of cephalosporin C separated from fermentation broths by ceramic membrane
- CIESC Journal Issue 7, Pages: 1632-1636(2006)
- 作者机构：
  
  南京工业大学膜科学技术研究所, 江苏省材料化学工程重点实验室,江苏,南京,210009
- 作者简介：
- 基金信息：
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- Online First：25 July 2006，
  
  Published：25 July 2006
- 稿件说明：
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WANG Longyao, XING Weihong, YANG Gang, et al. Estimation and control of yield of cephalosporin C separated from fermentation broths by ceramic membrane[J]. CIESC Journal, 2006, (7): 1632-1636.
DOI：

WANG Longyao, XING Weihong, YANG Gang, et al. Estimation and control of yield of cephalosporin C separated from fermentation broths by ceramic membrane[J]. CIESC Journal, 2006, (7): 1632-1636. DOI：

摘要

通过对头孢菌素C发酵液膜过滤过程的分析，引入了前浓缩比a、洗滤阶段稀释比b和后浓缩比c3个参数.针对采用连续洗滤操作模式和间歇洗滤操作模式的膜过滤过程，分别给出了总收率计算式和采用分段函数表示的过程收率计算式.通过计算比较了CFD和IFD操作模式下收率的变化情况，并进行了实验验证.结果表明，恰当选择的操作模式和参数值将有助于提高过程收率和缩短过滤时间，计算式能够为有效控制过滤过程收率提供理论依据.

Abstract

This paper is concerned with estimation and control of the yield in the process of clarifying fermentation broths for the production of cephalosporin C by ceramic membrane.Three parameters (volume concentration ratio in pre-concentration step

a; volume dilution ratio in diafiltration step

b; volume concentration ratio in post-concentration step

c) are introduced in the model to estimate the yield of cephalosporin C.The equations for estimating overall yield and the piecewise functions for estimating real-time yield are put forward.The yields are compared with the operation modes of continuous feed diafiltration (CFD) and intermittent feed diafiltration (IFD) by model calculation and experiment.The results show that the model is helpful for optimizing the microfiltration process by enhancing the yield and reducing the overall operation time.By using the model in this paper

the yield of cephalosporin C can be controlled effectively in the process of membrane filtration.

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