Omeprazole resolution by simulated moving bed chromatography

WEI Feng; SHEN Bo; CHEN Mingjie; ZHOU Xianbo; WU Pingdong

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Omeprazole resolution by simulated moving bed chromatography

更新时间：2025-12-10

- Omeprazole resolution by simulated moving bed chromatography
- CIESC Journal Issue 9, Pages: 1699-1702(2005)
- 作者机构：
  
  1. 浙江大学宁波理工学院生物与制药工程系,浙江,宁波,315100
  2. 浙江大学二次资源化工国家专业实验室,浙江,杭州,310027
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：25 September 2005，
  
  Published：25 September 2005
- 稿件说明：
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WEI Feng, SHEN Bo, CHEN Mingjie, et al. Omeprazole resolution by simulated moving bed chromatography[J]. CIESC Journal, 2005, (9): 1699-1702.
DOI：

WEI Feng, SHEN Bo, CHEN Mingjie, et al. Omeprazole resolution by simulated moving bed chromatography[J]. CIESC Journal, 2005, (9): 1699-1702. DOI：

摘要

以乙醇为流动相，用纤维素三苯基氨基甲酸酯涂敷型手性固定相在模拟移动床色谱上拆分了奥美拉唑对映体.研究了柱子切换时间以及流动相内部流速对分离效果的影响.实验条件下，S-奥美拉唑的浓度、产率和回收率随切换时间增加而增加，流动相消耗和纯度则随之降低.降低内部流速，有利于改善分离，S-奥美拉唑的纯度最高可达96.4%，R-奥美拉唑的纯度最高为88.4%.

Abstract

The enantiomers of omeprazole were resolved by simulated moving bed chromatography on the coated cellulose triphenylcarbamate chiral stationary phase using ethanol as mobile phase.The effects of columns switching time and recycling flow rate on separation were investigated.Under the experimental conditions

as the switching time was increased

the concentration

productivity and recovery of S-omeprazole were increased

while the consumption of eluent and the purity of enantiomer were decreased.Decreasing recycling flow rate could improve separation

and the highest purity of the two enantiomers was 96.4%(S) and 88.4%(R) respectively.

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