IN VITRO RELEASE KINETICS OF AMPHIPHILIC BLOCK COPOLYMER NANO-MICELLES LOADED WITH PACLITAXEL

ZHANG Yueting; DONG Anjie; DENG Liandong; YUAN Yingjin

您当前的位置：

首页 >

文章列表页 >

IN VITRO RELEASE KINETICS OF AMPHIPHILIC BLOCK COPOLYMER NANO-MICELLES LOADED WITH PACLITAXEL

更新时间：2025-12-10

- IN VITRO RELEASE KINETICS OF AMPHIPHILIC BLOCK COPOLYMER NANO-MICELLES LOADED WITH PACLITAXEL
- CIESC Journal Issue 6, Pages: 952-957(2004)
- 作者机构：
  
  天津大学化工学院,天津,300072
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：25 June 2004，
  
  Published：25 June 2004
- 稿件说明：
移动端阅览
ZHANG Yueting, DONG Anjie, DENG Liandong, et al. IN VITRO RELEASE KINETICS OF AMPHIPHILIC BLOCK COPOLYMER NANO-MICELLES LOADED WITH PACLITAXEL[J]. CIESC Journal, 2004, (6): 952-957.
DOI：

ZHANG Yueting, DONG Anjie, DENG Liandong, et al. IN VITRO RELEASE KINETICS OF AMPHIPHILIC BLOCK COPOLYMER NANO-MICELLES LOADED WITH PACLITAXEL[J]. CIESC Journal, 2004, (6): 952-957. DOI：

摘要

采用低分子量PEG-PCL-PEG、mPEG-PLLA、mPEG-PDLLA等两亲性嵌段共聚物作载体包载紫杉醇形成纳米胶束.研究了不同载药率胶束在磷酸缓冲液中释放的动力学，发现紫杉醇PEG-PCL-PEG胶束和mPEG-PLLA胶束的体外释药遵从一级释放动力学；紫杉醇mPEG-PDLLA纳米胶束的体外释放多呈现出两段零级释放动力学；低载药率胶束表现出高释药率；体外释药过程中磷酸缓冲液的更新量越大，紫杉醇的释放率越高.

Abstract

Different kinds of amphiphilic block copolymers

PEG-PCL-PEG(PECL)

mPEG-PLLA(PELLA) and mPEG-PDLLA(PEDLLA)，were used to encapsulate paclitaxel to prepare nano-micelle formulation. The nano-micelles had a core-shell structure

in which paclitaxel was enveloped in the core

and the PEG shell made the micelles loaded with paclitaxel lyotropic in water. The kinetics of paclitaxel release from the micelles in phosphate buffer solution(PBS) was studied.The results showed that the diameter of the micelles affected apparently drug release rate

and micelles with low drug loaded content(DLC) would release more paclitaxel; enhancing the refresh volume of PBS facilitated drug[DK]’s release; both PECL micelle and PELLA micelle released paclitaxel in PBS under the rule of first order equation; PEDLLA micelles loaded with paclitaxel prepared by solid dispersion technology obeyed zero-order release in two stage.

关键词

Keywords

references

Views

505

下载量

CSCD

Alert me when the article has been cited

提交

Tools

Publicity Resources

Performance analysis and application of thermal and humidity control system cascade driven by waste heat

Hydrolysis reaction mechanism of CNCl on the surface of composite metal CuCr2O4

Performance of alkali metal-loaded SrMnO3 oxygen carriers in chemical looping oxidative dehydrogenation of ethylbenzene

Mechanism and regulation of supercooling behavior in imidazolium-based ionic liquids

Zn-doped PdO/ZrO2 with rich oxygen vacancies for the synthesis of diphenyl carbonate from CO2 and phenol

Related Author

No data

Related Institution

No data

⁰