Among the techniques developed for bilinear data reconciliation problems

the method based on independent flows is well known in terms of both accuracy and efficiency. However

the independent flow method is not effective when reactor units are present in the process. In this paper

an extended independent flow method is proposed for the data reconciliation of the process with chemical reaction. By the new method

the independent flows finding algorithm is adjusted to avoid the difficulties caused by the reactors in the process

and the reaction constraints are introduced into the objective function of data reconciliation. As a result

the new method can be applied to the process with chemical reaction while retaining high solution accuracy. To test the performance

the new method and the most typical Crowe’s projection method are used in the data reconciliation of a typical industrial process. The results show that the new method can effectively accomplish the data reconciliation of the multicomponent process with chemical reaction and gives more accurate estimates than the Crowe’s method.