In this paper

methyl 2-(6-methoxy-2naphthyl)propionate（naproxen）was asymmetrically hydrolyzed by candida rugosa lipase in pseudo-eutectic and organic solvent systems. The result showed that S-(+)-naproxen with enantiomeric excess more than 95% could be obtained with commercially available candida rugosa lipase in both systems. In organic solvent system

24.1% reaction conversion of naproxen methylester could be obtained after 96 hours

while in pseudo-eutectic systems

the conversion was 40.1% after 72 h. Furthermore

only one fifth organic solvent volume was used in pseudo-eutectic systems.Compared to organic solvent systems

the effects of lipase concentration

substrate and water concentration

and several different kinds of adjuncts on reaction conversion were studied in pseudo-eutectic system. Also

under the optimium pseudo-eutectic enzymatic reaction conditions

the reaction conversion was 45.8%.