An agent-based approach for integration of chemical process operation systems is proposed. According to the scale of time response
the process operation systems are divided into three sub-systems:process monitoring and fault diagnosis
simulation and optimization
planning and scheduling
respectively. Their agent models are built accordingly. The integration is achieved by information integration and decision-making tasks integration.A case study is reported on multi-agent based integration of TE process. The result shows that global coordination and optimization of process operating systems is achieved with the proposed approach.