COMPARISON AND ANALYSIS OF DIFFERENT FED - BATCH METHODS ON FERMENTATION OF ERGOSTEROL

GAO Hua; TANG Fang; TAN Tianwei

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COMPARISON AND ANALYSIS OF DIFFERENT FED - BATCH METHODS ON FERMENTATION OF ERGOSTEROL

更新时间：2025-12-10

- COMPARISON AND ANALYSIS OF DIFFERENT FED - BATCH METHODS ON FERMENTATION OF ERGOSTEROL
- CIESC Journal Issue 12, (2002)
- 作者机构：
  
  北京化工大学生物化工系
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：25 December 2002，
  
  Published：25 December 2002
- 稿件说明：
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GAO Hua, TANG Fang, TAN Tianwei. COMPARISON AND ANALYSIS OF DIFFERENT FED - BATCH METHODS ON FERMENTATION OF ERGOSTEROL[J]. CIESC Journal, 2002, (12).
DOI：

GAO Hua, TANG Fang, TAN Tianwei. COMPARISON AND ANALYSIS OF DIFFERENT FED - BATCH METHODS ON FERMENTATION OF ERGOSTEROL[J]. CIESC Journal, 2002, (12). DOI：

摘要

研究了不同流加操作条件对实验用酵母菌的生物量和麦角固醇含量的影响

以提高麦角固醇的发酵水平.比较了恒速流加、恒残糖反馈流加、指数流加、控制溶氧的指数流加、脉冲流加、控制溶氧的脉冲流加等流加条件下pH值、溶氧、残糖浓度、生物量、麦角固醇含量等参数的变化

对相应的变化进行了讨论.结果表明

控制溶氧的脉冲式流加是一种较好的流加方式

与传统的发酵操作相比每升发酵液的麦角固醇产量提高了20％.

Abstract

The effects of different fed-batch methods on the biomass and ergosterol content in Saccharomyces cerevisiae were studied. The relationships of such parameters as pH

DO and concentration of glucose with biomass and ergoterol content were discussed under the circumstances of constant feed rate fed - batch

constant glucose - concentration fed - batch

exponential fed - batch

DO - control exponential fed - batch

pulse fed -batch

DO-control pulse fed-batch. Explanations and analysis of these phenomena were provided. According to the results of experiments

DO -control pulse fed- batch is an effective method for the fermentation of ergoterol. Compared with the traditional method

the actual yield (the product of biomass and ergoterol content) could be improved by 20% .

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