New process for preparing benazepril precursor

Kafssi Hassan; WANG Tao; WANG Fang; WAN Pingyu

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New process for preparing benazepril precursor

更新时间：2025-12-10

- New process for preparing benazepril precursor
- CIESC Journal Issue 10, Pages: 2558-2560(2007)
- 作者机构：
  
  北京化工大学
- 作者简介：
- 基金信息：
- DOI：
  CLC：
- Online First：05 October 2007，
  
  Published：05 October 2007
- 稿件说明：
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Kafssi Hassan, WANG Tao, WANG Fang, et al. New process for preparing benazepril precursor[J]. CIESC Journal, 2007, (10): 2558-2560.
DOI：

Kafssi Hassan, WANG Tao, WANG Fang, et al. New process for preparing benazepril precursor[J]. CIESC Journal, 2007, (10): 2558-2560. DOI：

摘要

本文采用两种过程制备盐酸贝那普利的前体[3-[(1-乙氧羰基-3-苯基丙基)-氨基]-2

5-四氢-2-氧代-1-H-1-苯并氮杂卓-1-乙酸叔丁酯(EPTAB)，并优化了其制备条件。异构体的分离采用柱层析分离。产品结构采用IR和NMR表征。

Abstract

The present work relates to a new synthesis process for the preparation of 3-（1-ethoxycarbonyl-3-phenylpropyl）-amino］-2，3，4，5-tetrahydro-2-oxo-1H-1-benzazepine-1-acetate tert butyl ester（EPTAB），the precursor of benazepril HClThe reaction conditions were optimized.The diastereomeric products were separated by flash column chromatography.The structures of the products were characterized with IR and NMR.

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