Oral colon-specific drug delivery system and its preparation

doi:10.3969/j.issn.0438-1157.2013.01.023

Abstract

Abstract: As the development and application of the fourth generation's drug dosage form, the oral colon-specific drug delivery system has the advantage of targeting orientation, increasing local drug concentration, acting on the lesion site directly, reducing drug dosage and side effect, etc.Aiming at the drug releasing mechanism, application and preparation technique, the research progress of this field is reviewed, so as to provide the theoretical basis and reference for the systematic research of the oral colon-specific drug delivery system.

Key words: colon-specific, drug delivery system, application, preparation

摘要： 口服结肠靶向给药系统作为第四代药物剂型的发展和应用,具有靶向定位性、可提高局部药物浓度、直接作用于病变部位、降低药物剂量、减少副反应等优点,因而备受研究者的关注。本文针对口服结肠靶向给药系统的给药机理、应用和制备技术,综述了该领域近些年来的研究进展,为系统研究口服结肠靶向给药系统提供理论依据和参考。

关键词: 结肠靶向, 给药系统, 应用, 制备

CLC Number:

Q819

WU Qingxi, YAO Shanjing. Oral colon-specific drug delivery system and its preparation[J]. CIESC Journal, 2013, 64(1): 210-222.

吴庆喜, 姚善泾. 口服结肠靶向给药系统和制备方法的研究进展[J]. 化工学报, 2013, 64(1): 210-222.

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