CIESC Journal ›› 2020, Vol. 71 ›› Issue (8): 3633-3643.DOI: 10.11949/0438-1157.20200003

• Separation engineering • Previous Articles     Next Articles

Study on crystallization separation of ursolic acid and oleanolic acid in ionic liquid

Yi GAO(),Yahui CAO,Jieping FAN()   

  1. School of Resource, Environmental and Chemical Engineering, Nanchang University, Nanchang 330031, Jiangxi, China
  • Received:2020-01-02 Revised:2020-06-03 Online:2020-08-05 Published:2020-08-05
  • Contact: Jieping FAN

离子液体中结晶分离熊果酸和齐墩果酸研究

高意(),曹亚慧,范杰平()   

  1. 南昌大学资源环境与化工学院,江西 南昌 330031
  • 通讯作者: 范杰平
  • 作者简介:高意(1996—),男,硕士研究生,835983980@qq.com
  • 基金资助:
    国家自然科学基金项目(21968017);江西省主要学科学术和技术带头人计划项目(20162BCB22010)

Abstract:

To expand the scope of crystallization solvent and improve the performance of crystallization separation of ursolic acid and oleanolic acid, ionic liquids were introduced as the crystallization solvent. The solubility data of ursolic acid and oleanolic acid in six ionic liquids + ethanol mixed solutions were measured. Then the 1-octyl-3-methylimidazole hexafluorophosphate + ethanol mixed solution was selected as the solvent for crystallization separation of ursolic acid and oleanolic acid, and the crystallization process was optimized by single factor experiments. The best process conditions are as follows: mass fraction of 1-octyl-3-methylimidazole hexafluorophosphat 5%, mass ratio of ursolic acid to oleanolic acid 1.5∶1, crystallization temperature 30℃, crystallization time 14 h. In this case, the mass fraction of oleanolic acid in the crystals can reach about 85%.

Key words: ursolic acid, oleanolic acid, ionic liquid, solubility, crystallization separation

摘要:

为拓展结晶溶剂的范围和提高结晶分离熊果酸和齐墩果酸的性能,引入离子液体作为结晶溶剂。测定了熊果酸和齐墩果酸在六种离子液体+乙醇溶液中的溶解度数据,根据该数据,选取1-辛基-3-甲基咪唑六氟磷酸+乙醇混合溶液作为溶剂对熊果酸和齐墩果酸进行了结晶分离,并采用单因素实验对结晶工艺进行了初步优化。结果表明:在1-辛基-3-甲基咪唑六氟磷酸质量分数5%,熊果酸和齐墩果酸质量比1.5∶1,结晶温度30℃,结晶时间14 h的条件下,结晶产物中齐墩果酸的质量分数可以达到85%左右。

关键词: 熊果酸, 齐墩果酸, 离子液体, 溶解度, 结晶分离

CLC Number: