CIESC Journal ›› 2020, Vol. 71 ›› Issue (10): 4783-4791.doi: 10.11949/0438-1157.20191604

• Biochemical engineering and technology • Previous Articles     Next Articles

Study on modification of NH2-MCM-41 and its pH-responsive drug release

Yanqin XU1(),Zhao QIN1(),Ye WANG1,Yuan CAO1(),Changguo CHEN1,Dan WANG2()   

  1. 1.School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, China
    2.State Key Laboratory of Coal Mine Disaster Dynamics and Control,Chongqing University,Chongqing 401331,China
  • Received:2020-01-02 Revised:2020-06-11 Online:2020-10-05 Published:2020-06-19
  • Contact: Yuan CAO,Dan WANG;201918131134@;;


Mesoporous silica (MCM-41) was synthesized by copolycondensation of tetraethoxysilane (TEOS) and 3-aminopropyltriethoxysilane (APTES). Firstly, it was modified with amino group. Then, four different drug carriers, Me-Ph-NH-MCM-41, OHC-Ph-NH-MCM-41, HO-Ph-NH-MCM-41, and HOOC-Ph-NH-MCM-41, were synthesized by grafting —R group (—R: —CHO, —OH, —CH3, —COOH), respectively. FT-IR, SEM, Zeta potential, and XRD were used to characterize its structure and morphology, indicating the successful synthesis of modified MCM-41. Rhodamine B (RhB) was used as a model for drug loading performance testing and the sensitive drug release behavior of this drug release system under different pH simulated humors was investigated. The effects of different —R groups on drug release were also explored. The results show that the four carriers hardly release drugs under neutral conditions. The drug release can be effectively controlled by changing the pH of the environmental system. The drug release behavior can be described by the Korsmeyer-Peppas kinetic model. The experiment showed that the drug release amount: RhB@HOOC-Ph-NH-MCM-41>RhB@OHC-Ph-NH-MCM-41>RhB@HO-Ph-NH-MCM-41>RhB@Me-Ph-NH-MCM-41. The pH-response of drug carriers with different —R groups was different, and the drug release amount of RhB@HOOC-Ph-NH-MCM-41 reached 57.87% at pH = 1.2, which has some potential applications in intelligent controlled release materials of drugs.

Key words: silica, synthesis, control, support, kinetic model

CLC Number: 

  • O 643.36


The schematic diagram of drug release"


XRD patterns of NH2-MCM-41 and four drug carriers"


N2 adsorption/desorption isotherm and pore size distribution of NH2-MCM-41 and four drug carriers"

Table 1

The pore structural parameter of NH2-MCM-41 and four drug carriers"






FT-IR spectra of NH2-MCM-41 and four drug carriers"


SEM images of four drug carriers"

Table 2

Zeta potential of NH2-MCM-41 and four drug carriers"


Table 3

The adsorption capacity and drug loading capacity of four drug carriers and NH2-MCM-41"


Table 4

Cumulative drug release percent of four drug carriers"





























Table 5

Results of drug release curve fitting of four drug carriers"



Cumulative release drug curves of four drug carriers at pH = 1.2, pH = 4.0 and pH = 7.4"

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